Appendicitis Overview
The appendix is a narrow
tubular pouch attached to the intestines. When the appendix is blocked,
it becomes inflamed and results in a condition termed appendicitis. If
the
blockage continues, the inflamed tissue becomes infected with bacteria
and begins to die from a lack of blood supply, which finally results in
the
rupture of the appendix
(perforated or ruptured appendix).
The American Journal of Epidemiology study found that appendicitis was a
common condition
affecting approximately 6.7% to 8.6% of the population. IN the U.S.
250,000
cases of appendicitis are reported annually. Individuals of any age may
be affected, with the highest incidence occurring
in the teens and twenties; however, rare cases of neonatal and prenatal
appendicitis have been reported. Increased vigilance in recognizing and
treating potential cases of appendicitis is critical
in the very young and elderly, as this population has a higher rate of
complications. Appendicitis is the most common pediatric condition
requiring emergency abdominal surgery.
Appendicitis Causes
There is no clear cause of appendicitis. Fecal material is thought to
be one possible cause of obstruction of the appendix. Bacteria,
viruses, fungi, and parasites can result in infection, leading to the
swelling of the tissues of the appendix wall. The various infecting
organisms include
Yersinia species, adenovirus, cytomegalovirus, actinomycosis, Mycobacteria species, Histoplasma species, Schistosoma species,
pinworms, and Strongyloides stercoralis.
Swelling of the tissue from inflammatory bowel disease such as
Crohn's disease also may cause appendicitis. Appendicitis is not a hereditary disease and is not transmittable from person to person.
Appendicitis Symptoms and Signs
Appendicitis typically begins with a vague pain in the middle of the abdomen
often near the navel or "belly button" (umbilicus). The pain slowly moves to the
right lower abdomen (toward the right hip) over the next 24 hours. In the
classic description, abdominal pain may be accompanied with
nausea,
vomiting, lack of appetite, and
fever.
All of these symptoms, however, occur in fewer than half of people who
develop appendicitis. More commonly, people with appendicitis have any
combination of these symptoms.
- Symptoms of appendicitis may take 4-48 hours to develop. During this time, a person developing appendicitis may have varying degrees of loss of appetite, vomiting, and abdominal pain. The person may have constipation or diarrhea, or there may be no change in bowel habits.
- Early symptoms are often hard to separate from other conditions including gastroenteritis (an inflammation of the stomach and intestines). Many people admitted to the hospital for suspected appendicitis leave the hospital with a diagnosis of gastroenteritis; initially, true appendicitis is often misdiagnosed as gastroenteritis.
- Children and the elderly often have fewer symptoms, or cannot adequately describe their symptoms, which makes their diagnosis less obvious and the incidence of complications more frequent.
When to Seek Medical Care
Call a health care practitioner if there are acute symptoms of middle/lower or right/lower
abdominal pain with fever and/or vomiting.
If symptoms of abdominal pain continue for more than four hours, an urgent medical evaluation should be
performed at the health care practitioner's office or a hospital's emergency department.
Appendicitis Diagnosis
Appendicitis is diagnosed by the classic symptoms of appendicitis and physical examination (the
health care practitioner's examination of
the patient's abdomen).
- Lab work: Although no blood test can confirm appendicitis, a blood sample is sent for laboratory analysis to check the white blood cell count, which is typically elevated in an individual with appendicitis. However, normal levels can be present with appendicitis, and elevated levels can be seen with other conditions. A urinalysis may be ordered to exclude urinary tract infection (or pregnancy) as the cause of the patient's symptoms.
- Imaging tests: Imaging tests are ordered when the diagnosis is not readily apparent. Most medical centers utilize a CT scan of the abdomen and pelvis to assist in evaluating abdominal pain suspected of being caused by appendicitis. Ultrasound scanning is commonly used in small children to test for appendicitis in order to avoid exposing the child to radiation from CT scans.
Other conditions that cause abdominal pain may mimic the symptoms of
appendicitis making the diagnosis more difficult. These conditions include
kidney stones, urinary tract infections, hernias, gallstones and gallbladder
problems, colitis, diverticulitis, and ovarian or testicular problems.
Appendicitis Treatment
Appendicitis Self-Care at Home
There is no home care for appendicitis. If appendicitis
is suspected, contact a health care practitioner or go to an emergency department. Avoid eating
or drinking as this may complicate or delay surgery. If you are thirsty, you may
rinse your mouth with water. Do not use laxatives, antibiotics, or pain medications because these may cause delay in diagnosis
that increases the risk of rupture of the appendix or mask the symptoms, which makes diagnosis more difficult.
Surgery (Appendectomy)
The best treatment for appendicitis is surgery to remove the appendix
(appendectomy) before the appendix ruptures. While awaiting surgery,
the patient will be given IV fluids to keep well hydrated. The patient
will not be allowed to eat or drink because doing so may cause
complications with the anesthesia during surgery.
Surgery is commonly performed via
laparoscopy, a minimally
invasive procedure where small "keyhole" incisions are made in the abdomen and
the appendix is removed with the assistance of a small camera guided by the
surgeon. However, in some cases it may be necessary to do an open abdominal procedure to
remove the appendix.
Occasionally, surgery for appendicitis reveals a non-inflamed
appendix (negative appendectomy),
with high rates in infants, the elderly, and young women. However, the
use
of imaging studies (CT scans, ultrasounds) appears to have reduced the
negative
appendectomy rate to 7%-12%. The difficulty in making a definite
diagnosis of this medical problem and the risk of missing
an acutely inflamed appendix (and the patient becoming very ill due to
perforation) makes a certain rate of misdiagnosis inevitable. Women in
particular have a high rate of negative appendectomy as ovarian and
uterine problems make the diagnosis more difficult. CT scanning prior
to surgery has been shown to decrease this percentage to closer to 7%
to 8% in women.
Appendicitis Follow-up
After an uncomplicated appendectomy, recovery time can vary from 2-6
weeks. The individual may gradually resume a normal diet with
restriction in physical activity for at least two to four weeks. The
health care practitioner will inspect the incision the following week to
look for possible wound infection.
Appendicitis Prevention
There is no way of predicting when appendicitis will occur or prevent it from
occurring.
There are no proven risk factors for appendicitis. It has been suggested that
potential risk factors may include a diet low in fiber and high in sugar, family
history, and infection.
Appendicitis Prognosis
- With uncomplicated appendicitis, most people recover with no long-term complications.
- If the appendix ruptures, there is a greater risk of complications, including death. This increase in risk generally is found in the very young, elderly, and those with weakened immune systems, including people with diabetes.
- Whether a perforated appendix is a significant risk for infertility has not been well established. Some experts recommend that this be considered in young women who might be at risk.